Hurt Blocker

The next big pain drug may soothe sensory firestorms without side effects

Michael Morgenstern

Among a small number of related families from northern Pakistan, some individuals never feel pain in any part of their bodies. Scientists studying six such children found that by the age of 4, they all had injuries to the lips or tongue from repeatedly biting themselves. Bruises, cuts and broken bones were common, though fractures were diagnosed only long after the fact, when weird, painless limping or the inability to use a limb called attention to the injury. Tests showed that the pain-free children perceived sensations of warm and cold, tickling and pressure.